Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems.

ABSTRACT: Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. This knowledge will help scientists find approaches to manipulate tumor and pathologic cells in order to enhance cellular sensitivity to therapeutics and treat them. Although some conventional therapeutics suffer from poor solubility, bioavailability and controlled release mechanisms, it appears that novel nanoplatforms overcome these obstacles and have led to the design of a theranostic-con

SUBMITTER: Tavakol S 

PROVIDER: S-EPMC6843293 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature