Helicobacter pylori Stress-Response: Definition of the HrcA Regulon.

ABSTRACT: Bacteria respond to different environmental stresses by reprogramming the transcription of specific genes whose proper expression is critical for their survival. In this regard, the heat-shock response, a widespread protective mechanism, triggers a sudden increase in the cellular concentration of different proteins, including molecular chaperones and proteases, to preserve protein folding and maintain cellular homeostasis. In the medically important gastric pathogen Helicobacter pylori the regulation of the principal heat-shock genes is under the transcriptional control of two repressor proteins named HspR and HrcA. To define the HrcA regulon, we carried out whole transcriptome analysis through RNA-sequencing, comparing the transcriptome of the H. pylori G27 wild type strain

SUBMITTER: Roncarati D 

PROVIDER: S-EPMC6843607 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature