The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.

ABSTRACT: We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.

SUBMITTER: Formicola B 

PROVIDER: S-EPMC6844026 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature