Overexpression of the Pluripotent Stem Cell Marker Podocalyxin in Prostate Cancer.

ABSTRACT:

Background/aim

Podocalyxin, a member of the CD34 family of cell surface sialomucins, is overexpressed in human embryonal carcinoma cell lines, as well as in several cancer types, and is associated with poor prognosis. Podocalyxin variants are associated with an increased risk and aggressiveness of prostate cancer. Herein podocalyxin protein expression in prostate cancer was characterized.

Materials and methods

Expression of podocalyxin as well as of TRA-1-60 and TRA-1-81 antigens was assessed immunohistochemically in 84 radical prostatectomy specimens and in adjacent normal tissues.

Results

Podocalyxin expression and H-scores were considerably higher in prostate tumors compared to normal tissues. High TRA-1-60 and TRA-1-81 staining was detected, however, in a much sma

SUBMITTER: Heath EI 

PROVIDER: S-EPMC6844084 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature