Modular organization of cerebellar climbing fiber inputs during goal-directed behavior.

ABSTRACT: The cerebellum has a parasagittal modular architecture characterized by precisely organized climbing fiber (CF) projections that are congruent with alternating aldolase C/zebrin II expression. However, the behavioral relevance of CF inputs into individual modules remains poorly understood. Here, we used two-photon calcium imaging in the cerebellar hemisphere Crus II in mice performing an auditory go/no-go task to investigate the functional differences in CF inputs to modules. CF signals in medial modules show anticipatory decreases, early increases, secondary increases, and reward-related increases or decreases, which represent quick motor initiation, go cues, fast motor behavior, and positive reward outcomes. CF signals in lateral modules show early increases and reward-related decreases,

SUBMITTER: Tsutsumi S 

PROVIDER: S-EPMC6844646 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature