Antipruritic Placebo Effects by Conditioning H1-antihistamine.

ABSTRACT: OBJECTIVE:Allergic rhinitis symptoms can be reduced by behaviorally conditioning antihistamine. It is unclear whether these findings extend to histamine-induced itch or work when participants are informed about the conditioning procedure (open-label conditioning). The current study aims to investigate the efficacy of (open-label) antipruritic behavioral conditioning for histamine-induced itch. METHODS:Healthy participants (n = 92; 84% female) were randomized to I) an open-label conditioned, II) closed-label conditioned, III) conditioned-not-evoked control, or IV) nonconditioned control group. A two-phase conditioning paradigm was used. During acquisition, a conditioned stimulus (CS; distinctively tasting beverage) was repeatedly paired with the H1-antihistamine levocetirizine (groups I-III

SUBMITTER: Meeuwis SH 

PROVIDER: S-EPMC6844655 | biostudies-literature | 2019 Nov/Dec

REPOSITORIES: biostudies-literature