Testosterone Treatment in Infants With 47,XXY: Effects on Body Composition.

ABSTRACT:

Context

Boys with XXY have greater adiposity and a higher risk of cardiovascular disease. Infants with XXY have lower testosterone concentrations than typical boys, but no studies have evaluated adiposity in infants with XXY or the physiologic effects of giving testosterone replacement.

Objective

To determine the effect of testosterone on body composition in infants with XXY.

Design

Prospective, randomized trial.

Setting

Tertiary care pediatric referral center.

Participants

20 infants 6 to 15 weeks of age with 47,XXY.

Intervention

Testosterone cypionate 25 mg intramuscularly monthly for three doses vs no treatment.

Main outcome measures

Difference in change in adiposity (percent fat mass z scores); other body composition measures, pe

SUBMITTER: Davis SM 

PROVIDER: S-EPMC6846330 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature