The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells.

ABSTRACT: The glucocorticoid and progesterone receptors (GR and PR) are closely related members of the steroid receptor family. Despite sharing similar structural and functional characteristics; the cognate hormones display very distinct physiological responses. In mammary epithelial cells, PR activation is associated with the incidence and progression of breast cancer, whereas the GR is related to growth suppression and differentiation. Despite their pharmacological relevance, only a few studies have compared GR and PR activities in the same system. Using a PR+/GR+ breast cancer cell line, here we report that either glucocorticoid-free or dexamethasone (DEX)-activated GR inhibits progestin-dependent gene expression associated to epithelial-mesenchymal-transition and cell proliferation. When both re

SUBMITTER: Ogara MF 

PROVIDER: S-EPMC6846950 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature