Histamine H₁ receptor on astrocytes and neurons controls distinct aspects of mouse behaviour.

ABSTRACT: Histamine is an important neurotransmitter that contributes to various processes, including the sleep-wake cycle, learning, memory, and stress responses. Its actions are mediated through histamine H₁-H₄ receptors. Gene knockout and pharmacological studies have revealed the importance of H₁ receptors in learning and memory, regulation of aggression, and wakefulness. H₁ receptors are abundantly expressed on neurons and astrocytes. However, to date, studies selectively investigating the roles of neuronal and astrocytic H₁ receptors in behaviour are lacking. We generated novel astrocyte- and neuron-specific conditional knockout (cKO) mice to address this gap in knowledge. cKO mice showed cell-specific reduction of H₁ receptor ge

SUBMITTER: Karpati A 

PROVIDER: S-EPMC6848115 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature