Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes.

ABSTRACT: A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen)₂(dppz)]²⁺ with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the Λ enantiomer was enhanced much more than the Δ. Despite this, the effect of each enantiomer on i-motif thermal stability was comparable. The sequences most affected by [Ru(phen)₂(dppz)]²⁺ were those with long thymine loops; this suggests that long-looped i-motifs are attractive targets for potential transition metal complex drugs and should be explored further in drug design.

SUBMITTER: Pages BJ 

PROVIDER: S-EPMC6848161 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature