Proteomic analysis of eleven tissues in the Chinese giant salamander (Andrias davidianus).

ABSTRACT: The Chinese giant salamander (Andrias davidianus, CGS) is the largest extant amphibian species in the world. Global quantitative proteome analysis of multiple tissues would indicate tissue-specific physiological processes and clarify the function of each protein from a whole-organism perspective. This study performed proteome analysis of eleven tissues collected from adult CGSs using iTRAQ coupled with LC-MS/MS technology. Based on the predicted protein database from previously obtained CGS transcriptome data, 2153 proteins were identified for subsequent analysis. A weighted gene co-expression network analysis (WGCNA) clustered 2153 proteins into 17 co-expressed modules, which will be useful for predicting the functions of unannotated proteins. The protein levels of molecular complexes wit

SUBMITTER: Geng X 

PROVIDER: S-EPMC6848178 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature