The relationship between childhood trauma, dopamine release and dexamphetamine-induced positive psychotic symptoms: a [¹¹C]-(+)-PHNO PET study.

ABSTRACT: Childhood trauma is a risk factor for psychosis. Amphetamine increases synaptic striatal dopamine levels and can induce positive psychotic symptoms in healthy individuals and patients with schizophrenia. Socio-developmental hypotheses of psychosis propose that childhood trauma and other environmental risk factors sensitize the dopamine system to increase the risk of psychotic symptoms, but this remains to be tested in humans. We used [¹¹C]-(+)-PHNO positron emission tomography to measure striatal dopamine-2/3 receptor (D_2/3R) availability and ventral striatal dexamphetamine-induced dopamine release in healthy participants (n = 24). The relationships between dexamphetamine-induced dopamine release, dexamphetamine-induced positive psychotic symptoms using the Positive a

SUBMITTER: Dahoun T 

PROVIDER: S-EPMC6848217 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature