Mass Cytometry Reveals a Sustained Reduction in CD16⁺ Natural Killer Cells Following Chemotherapy in Colorectal Cancer Patients.

ABSTRACT: The immune system and inflammation plays a significant role in tumour immune evasion enhancing disease progression and reducing survival in colorectal cancer (CRC). Patients with advanced stages of colorectal cancer will all undergo treatment with cytotoxic chemotherapy which may alter the complexity of immune cell populations. This study used mass cytometry to investigate the circulating immune cell profile of advanced CRC patients following acute and chronic doses of standard cytotoxic chemotherapy and analysed seven major immune cell populations and over 20 subpopulations. Unsupervised clustering analysis of the mass cytometry data revealed a decrease in NK cells following one cycle of cytotoxic chemotherapy. Investigation into the NK sub-population revealed a decline in the CD56^di

SUBMITTER: Shinko D 

PROVIDER: S-EPMC6848231 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature