Temporal Dynamics of Diffusion Metrics in Early Multiple Sclerosis and Clinically Isolated Syndrome: A 2-Year Follow-Up Tract-Based Spatial Statistics Study.

ABSTRACT: Background: Tract-based spatial statistics (TBSS) is suitable for the assessment of voxel-wise changes in fiber integrity in WM tracts in the entire brain. Longitudinal TBSS analyses of early multiple sclerosis (MS) using 3 Tesla magnetic resonance imaging (MRI) are not common. Objective: To characterize microstructural WM alterations at initial diagnosis in clinically isolated syndrome (CIS) and early MS at baseline and longitudinally over 2 years. Methods: DTI (Diffusion tensor imaging) at 3 Tesla was used to evaluate 106 therapy-naive patients with CIS or definite MS at baseline and at 1-year (N = 83) and 2-year (N = 43) follow-up compared to healthy controls (HC, N = 49). TBSS was used for voxel-wise analyses of the DTI indices of fractional an

SUBMITTER: Schneider R 

PROVIDER: S-EPMC6848258 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature