Intestinal Epithelium Modulates Macrophage Response to Gliadin in Celiac Disease.

ABSTRACT: Celiac disease is an immune-mediated enteropathy triggered by ingestion of gluten. Although its pathogenesis has been extensively studied and the contribution from both innate and adaptive immune responses has been reported, little is still known about the contribution of macrophages to the onset or maintenance of the disease. Macrophages are extremely plastic immune cells that can be directed toward a pro- or anti-inflammatory phenotype by the surrounding microenvironment. Of note, gliadin, the most prominent causative agent of the disease, has been reported to trigger the production of pro-inflammatory cytokines in this cell population. In the present study, we aimed at investigating how the intestinal milieu and more specifically the epithelium can shape the macrophage response to gliad

SUBMITTER: Serena G 

PROVIDER: S-EPMC6848268 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature