Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila.

ABSTRACT: The coordinated growth and development of synapses is critical for all aspects of neural circuit function and mutations that disrupt these processes can result in various neurological defects. Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway, regulate synaptic development in vertebrates and invertebrates. At the Drosophila larval neuromuscular junction (NMJ), the retrograde BMP pathway is a part of the machinery that controls NMJ expansion concurrent with larval growth. We sought to determine whether the conserved Hippo pathway, critical for proportional growth in other tissues, also functions in NMJ development. We found that neuronal loss of the serine-threonine protein kinase Tao, a regulator of the Hippo signaling pat

SUBMITTER: Politano SF 

PROVIDER: S-EPMC6848449 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature