Benefits and Harms of Mammography Screening for Women With Down Syndrome: a Collaborative Modeling Study.

ABSTRACT:

Background

Women with Down syndrome have a lower breast cancer risk and significantly lower life expectancies than women without Down syndrome. Therefore, it is not clear whether mammography screening strategies used for women without Down syndrome would benefit women with Down syndrome in the same way.

Objective

To determine the benefits and harms of various mammography screening strategies for women with Down syndrome using collaborative simulation modeling.

Design

Two established Cancer Intervention and Surveillance Modeling Network (CISNET) simulation models estimated the benefits and harms of various screening strategies for women with Down syndrome over a lifetime horizon.

Participants

We modeled a hypothetical cohort of US women with Down syndrome who we

SUBMITTER: Alagoz O 

PROVIDER: S-EPMC6848489 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature