Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction.

ABSTRACT:

Research question

Studies in rodents have shown that paternal folate intake prior to conception is associated with pregnancy and offspring outcomes. The aim of this study was to assess whether those associations might apply to humans as well.

Design

Between 2007 and 2017, the study prospectively analysed data from 108 couples participating in a preconception cohort of couples undergoing fertility treatment using their own gametes, whose treatment resulted in 113 pregnancies during the course of the study. Paternal and maternal preconception folate intake was assessed using a validated food frequency questionnaire. Linear mixed models were used to assess whether paternal preconception folate intake was associated with gestational age at delivery and gestational age-specific b

SUBMITTER: Martin-Calvo N 

PROVIDER: S-EPMC6848767 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature