Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus.

ABSTRACT: Interest in the high folate status of pregnant women has increased due to its role in the prevention of neural tube defects (NTDs). The effect of increased red blood cell (RBC) folate status during the second trimester of pregnancy on gestational diabetes mellitus (GDM) remains unclear. We measured RBC folate concentrations by competitive protein-binding assay and obtained clinical information from electronic medical records. Logistic regression analysis was used to explore the associations of RBC folate concentrations with risks of gestational diabetes mellitus (GDM). We further assessed the potential nonlinear relations between continuous log-transformed RBC folate concentrations and GDM risk by using the restricted cubic splines. We observed high RBC folate concentrations in GDM patient

SUBMITTER: Xie K 

PROVIDER: S-EPMC6848811 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature