Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual survival of COPD patients are of great value. We analyzed baseline molecular profiles and collected 54 months of follow-up data of the cohort study "COPD and SYstemic consequences-COmorbidities NETwork" (COSYCONET). Genome-wide microRNA signatures from whole blood collected at time of the inclusion in the study were generated for 533 COPD patients including patients that deceased during the 54-month follow-up period (n = 53) and patients that survived this period (n = 480). We iden

SUBMITTER: Keller A 

PROVIDER: S-EPMC6848926 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature