Lifetime risk of knee and hip replacement following a diagnosis of RA: findings from a cohort of 13 961 patients from England.

ABSTRACT:

Objective

To estimate the lifetime risk of knee and hip replacement following a diagnosis of RA.

Methods

The analysis was undertaken using routinely collected data from the English NHS. Diagnosis of RA was identified using primary care records, with knee and hip replacement observed in linked hospital records. Parametric survival models were fitted for up to 15 years of follow-up, with age, sex, Charlson comorbidity score, socioeconomic status, BMI and smoking status included as explanatory variables. A decision model was used to combine and extrapolate survival models to estimate lifetime risk.

Results

The number of individuals with a diagnosis of RA and included in the study was 13 961. Lifetime risk of knee replacement and hip replacement was estimated to be 22% (9

SUBMITTER: Burn E 

PROVIDER: S-EPMC6848958 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature