Estimating the Genome-wide Mutation Rate with Three-Way Identity by Descent.

ABSTRACT: The two primary methods for estimating the genome-wide mutation rate have been counting de novo mutations in parent-offspring trios and comparing sequence data between closely related species. With parent-offspring trio analysis it is difficult to control for genotype error, and resolution is limited because each trio provides information from only two meioses. Inter-species comparison is difficult to calibrate due to uncertainty in the number of meioses separating species, and it can be biased by selection and by changing mutation rates over time. An alternative class of approaches for estimating mutation rates that avoids these limitations is based on identity by descent (IBD) segments that arise from common ancestry within the past few thousand years. Existing IBD-based methods are limi

SUBMITTER: Tian X 

PROVIDER: S-EPMC6848988 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature