Prognostic Implication of Adrenocortical Response during the Course of Critical Illness.

ABSTRACT:

Background

Critical illness-related corticosteroid insufficiency (CIRCI) and adrenocorticotropic hormone (ACTH)-cortisol dissociation are hormonal conditions frequently observed in patients in the intensive care unit (ICU). The aim of this study was to evaluate the association between ACTH-cortisol dissociation and clinical outcomes of critically ill patients.

Methods

We retrospectively reviewed the medical records of 94 ICU patients who underwent two rapid cosyntropin tests during hospital admission and compared the clinical aspects of patients with and without ACTH-cortisol dissociation. ACTH-cortisol dissociation was defined as plasma ACTH and serum cortisol concentrations of <22 pmol/L and >600 nmol/L, respectively.

Results

Dissociation was present in 30 of the 94

SUBMITTER: Song JH 

PROVIDER: S-EPMC6849045 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature