Role of ethambutol and rifampicin in the treatment of Mycobacterium avium complex pulmonary disease.

ABSTRACT:

Background

A three-drug regimen (macrolide, ethambutol, and rifampicin) is recommended for the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD). Although macrolide has proven efficacy, the role of ethambutol and rifampicin in patients without acquired immune deficiency syndrome is not proven with clinical studies. We aimed to clarify the roles of ethambutol and rifampicin in the treatment of MAC-PD.

Methods

Patients treated for MAC-PD between March 1st, 2009 and October 31st, 2018 were reviewed retrospectively. Rates of culture conversion, microbiological cure, treatment failure, and recurrence were compared according to the maintenance (≥6 months) of ethambutol or rifampicin with macrolide.

Results

Among the 237 patients, 122 (51.5%) maintained eth

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC6849249 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature