DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens.

ABSTRACT:

Background

The maintenance of genomic integrity is the responsibility of a complex network, denominated the DNA damage response (DDR), which controls the lesion detection and DNA repair. The main repair pathways are base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination repair (HR) and non-homologous end joining repair (NHEJ). They correct double-strand breaks (DSB), single-strand breaks, mismatches and others, or when the damage is quite extensive and repair insufficient, apoptosis is activated.

Methods

In this study we used the BLAST reciprocal best-hit methodology to search for DDR orthologs proteins in Aedes aegypti. We also provided a comparison between Ae. aegypti, D. melanogaster and human DDR network.

Results<

SUBMITTER: Mota MBS 

PROVIDER: S-EPMC6849265 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature