Early lactate measurement is associated with better outcomes in septic patients with an elevated serum lactate level.

ABSTRACT:

Background

The optimal timing of lactate measurement for septic patients in the intensive care unit (ICU) remains controversial, and whether initiating and repeating the lactate measurement earlier could make a difference for septic patients with an elevated lactate level remains unexplored.

Methods

This was a retrospective observational study that included septic patients with an initial lactate level > 2.0 mmol/L after ICU admission, and all data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. The main exposure of interest was the early lactate measurement, which was defined as an initial lactate level measurement within 1 h after ICU admission. The primary outcome was 28-day mortality.

Results

A total of 2642 eligible s

SUBMITTER: Chen H 

PROVIDER: S-EPMC6849274 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature