Pre-stimulus beta power modulation during motor sequence learning is reduced in 'Parkinson's disease.

ABSTRACT: Beta oscillations within motor-cortical areas have been linked to sensorimotor function. In line with this, pathologically altered beta activity in cortico-basal ganglia pathways has been suggested to contribute to the pathophysiology of Parkinson's disease (PD), a neurodegenerative disorder primarily characterized by motor impairment. Although its precise function is still discussed, beta activity might subserve an anticipatory role in preparation of future actions. By reanalyzing previously published data, we aimed at investigating the role of pre-stimulus motor-cortical beta power modulation in motor sequence learning and its alteration in PD. 20 PD patients and 20 healthy controls (HC) performed a serial reaction time task (SRTT) in which reaction time gain presumably reflects the abil

SUBMITTER: Meissner SN 

PROVIDER: S-EPMC6849445 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature