Late Effects of Radiation Prime the Brain Microenvironment for Accelerated Tumor Growth.

ABSTRACT:

Purpose

Glioblastoma (GBM) remains incurable, despite state-of-the-art treatment involving surgical resection, chemotherapy, and radiation. GBM invariably recurs as a highly invasive and aggressive phenotype, with the majority of recurrences within the radiation therapy treatment field. Although a large body of literature reporting on primary GBM exists, comprehensive studies of how prior irradiation alters recurrent tumor growth are lacking. An animal model that replicates the delayed effects of radiation therapy on the brain microenvironment, and its impact on the development of recurrent GBM, would be a significant advance.

Methods and materials

Cohorts of mice received a single fraction of 0, 20, 30, or 40 Gy Gamma Knife irradiation. Naïve, nonirradiated mouse GBM tumor

SUBMITTER: Duan C 

PROVIDER: S-EPMC6849509 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature