Parental asthma and risk of autism spectrum disorder in offspring: A population and family-based case-control study.

ABSTRACT:

Background

Associations between parental asthma and prenatal exposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported. However, the associations might be confounded by unmeasured (genetic and shared environmental) familial factors.

Objective

We investigated the association between (a) maternal/paternal asthma and offspring ASD, and (b) prenatal exposures to β2-agonists, other asthma medications and offspring ASD using cases and controls selected from the population as well as biological relatives with different degrees of relatedness.

Methods

We included all children (N = 1 579 263) born in Sweden 1992-2007. A nested case-control design was used to compare 22 894 ASD cases identified from the National Patient Register to (a) 228 

SUBMITTER: Gong T 

PROVIDER: S-EPMC6849600 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature