Selective single C-F bond arylation of trifluoromethylalkene derivatives.

ABSTRACT: A strategically novel single C-F bond functionalization of CF₃-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of S_N2' amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF₃-alkene and arylboronic acid derivatives.

SUBMITTER: Tang L 

PROVIDER: S-EPMC6849639 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature