HCN4 knockdown in dorsal hippocampus promotes anxiety-like behavior in mice.

ABSTRACT: Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels mediate the I_h current in the murine hippocampus. Disruption of the I_h current by knockout of HCN1, HCN2 or tetratricopeptide repeat-containing Rab8b-interacting protein has been shown to affect physiological processes such as synaptic integration and maintenance of resting membrane potentials as well as several behaviors in mice, including depressive-like and anxiety-like behaviors. However, the potential involvement of the HCN4 isoform in these processes is unknown. Here, we assessed the contribution of the HCN4 isoform to neuronal processing and hippocampus-based behaviors in mice. We show that HCN4 is expressed in various regions of the hippocampus, with distinct expression patterns that partia

SUBMITTER: Gunther A 

PROVIDER: S-EPMC6850037 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature