How clonal are clones? A quest for loss of heterozygosity during asexual reproduction in Daphnia magna.

ABSTRACT: Due to the lack of recombination, asexual organisms are predicted to accumulate mutations and show high levels of within-individual allelic divergence (heterozygosity); however, empirical evidence for this prediction is largely missing. Instead, evidence of genome homogenization during asexual reproduction is accumulating. Ameiotic crossover recombination is a mechanism that could lead to long genomic stretches of loss of heterozygosity (LOH) and unmasking of mutations that have little or no effect in heterozygous state. Therefore, LOH might be an important force for inducing variation among asexual offspring and may contribute to the limited longevity of asexual lineages. To investigate the genetic consequences of asexuality, here we used high-throughput sequencing of Daphnia magna for as

SUBMITTER: Dukic M 

PROVIDER: S-EPMC6850383 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature