The willingness to participate in biomedical research involving human beings in low- and middle-income countries: a systematic review.

ABSTRACT: OBJECTIVES:To systematically review reasons for the willingness to participate in biomedical human subjects research in low- and middle-income countries (LMICs). METHODS:Five databases were systematically searched for articles published between 2000 and 2017 containing the domain of 'human subjects research' in 'LMICs' and determinant 'reasons for (non)participation'. Reasons mentioned were extracted, ranked and results narratively described. RESULTS:Ninety-four articles were included, 44 qualitative and 50 mixed-methods studies. Altruism, personal health benefits, access to health care, monetary benefit, knowledge, social support and trust were the most important reasons for participation. Primary reasons for non-participation were safety concerns, inconvenience, stigmatisation, lack of s

SUBMITTER: Browne JL 

PROVIDER: S-EPMC6850431 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature