Effects of variants of 50 genes on diabetes risk among the Chinese population born in the early 1960s.

ABSTRACT:

Background

Genome-wide association studies have identified loci that significantly increase diabetes risk. This study explored the genetic susceptibility in relation to diabetes risk in adulthood among a Chinese population born in the early 1960s.

Methods

In all, 2129 subjects (833 males, 1296 females) were selected from the cross-sectional 2010 to 2012 China National Nutrition and Health Survey. Fifty diabetes-related single nucleotide polymorphisms (SNPs) were detected. Two diabetes genetic risk scores (GRSs) based on the 50 diabetes-predisposing variants were developed to examine the association of these SNPs with diabetes risk.

Results

Associations were found between diabetes risk and SNPs in the MTNR1B (rs10830963), KLHDC5 (rs10842994), GRK5 (rs10886471), cyclind

SUBMITTER: Song C 

PROVIDER: S-EPMC6850447 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature