Population pharmacokinetics of brodalumab in patients with moderate to severe plaque psoriasis.

ABSTRACT: Brodalumab is a fully human monoclonal antibody targeting the IL-17 receptor A leading to an inhibition of the biological effect of IL-17A, IL-17F, IL-17A/F heterodimer, IL-17C and IL-17E isoforms. It has shown to be efficacious in the treatment of moderate to severe plaque psoriasis (210 mg administered subcutaneously at weeks 0, 1 and 2 followed by 210 mg every 2 weeks [Q2W+1]). A population pharmacokinetic model based on psoriasis patients only from six clinical trials was developed to describe the pharmacokinetics and identify sources of variability. In patients with psoriasis, Brodalumab exhibits non-linear pharmacokinetics due to target-mediated drug disposition resulting in concentration-dependent clearance. The pharmacokinetics was best described by a two-compartment model with lin

SUBMITTER: Timmermann S 

PROVIDER: S-EPMC6850607 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature