Creation of a Curated Aquatic Toxicology Database: EnviroTox.

ABSTRACT: Flexible, rapid, and predictive approaches that do not require the use of large numbers of vertebrate test animals are needed because the chemical universe remains largely untested for potential hazards. Development of robust new approach methodologies and nontesting approaches requires the use of existing information via curated, integrated data sets. The ecological threshold of toxicological concern (ecoTTC) represents one such new approach methodology that can predict a conservative de minimis toxicity value for chemicals with little or no information available. For the creation of an ecoTTC tool, a large, diverse environmental data set was developed from multiple sources, with harmonization, characterization, and information quality assessment steps to ensure that the information could

SUBMITTER: Connors KA 

PROVIDER: S-EPMC6850623 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature