Preventive chemotherapy reverses covert, lymphatic-associated tissue change in young people with lymphatic filariasis in Myanmar.

ABSTRACT:

Objectives

This longitudinal comparative study investigated the effect of preventive chemotherapy (PC) on covert tissue changes associated with lymphatic filariasis (LF) among young people living in an LF-endemic area in Myanmar.

Methods

Tissue compressibility and extracellular free fluid in the lower limbs of people aged 10-21 years were measured using indurometry and bioimpedance spectroscopy (BIS). Baseline measures were taken in October 2014, annual mass drug administration (MDA) of PC was delivered in December, and in March 2015 further PC was offered to LF-positive cases who had missed MDA. Follow-up measures were taken in February and June 2015.

Results

A total of 50 antigen-positive cases and 46 antigen-negative controls were included. Self-reported PC consump

SUBMITTER: Douglass J 

PROVIDER: S-EPMC6850631 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature