New formulation of the Gompertz equation to describe the kinetics of untreated tumors.

ABSTRACT:

Background

Different equations have been used to describe and understand the growth kinetics of undisturbed malignant solid tumors. The aim of this paper is to propose a new formulation of the Gompertz equation in terms of different parameters of a malignant tumor: the intrinsic growth rate, the deceleration factor, the apoptosis rate, the number of cells corresponding to the tumor latency time, and the fractal dimensions of the tumor and its contour.

Methods

Furthermore, different formulations of the Gompertz equation are used to fit experimental data of the Ehrlich and fibrosarcoma Sa-37 tumors that grow in male BALB/c/Cenp mice. The parameters of each equation are obtained from these fittings.

Results

The new formulation of the Gompertz equation reveals that the in

SUBMITTER: Castaneda ARS 

PROVIDER: S-EPMC6850893 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature