Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats.

ABSTRACT: Thus far, the cellular and molecular mechanisms related to early (especially within 24 hours after acute myocardial infarct (MI)) exercise-mediated beneficial effects on MI have not yet been thoroughly established. In the present study, we demonstrated that acute MI rats that underwent early moderate exercise training beginning one day after MI showed no increase in mortality and displayed significant improvements in MI healing and ventricular remodelling, including an improvement in cardiac function, a decrease in infarct size, cardiomyocyte apoptosis, cardiac fibrosis and cardiomyocyte hypertrophy, and an increase in myocardial angiogenesis, left ventricular wall thickness and the number of cardiac telocytes in the border zone. Integrated miRNA-mRNA profiling analysis performed by the in

SUBMITTER: Liao Z 

PROVIDER: S-EPMC6850916 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature