FAConstructor: an interactive tool for geometric modeling of nerve fiber architectures in the brain.

ABSTRACT:

Purpose

The technique 3D polarized light imaging (3D-PLI) allows to reconstruct nerve fiber orientations of postmortem brains with ultra-high resolution. To better understand the physical principles behind 3D-PLI and improve the accuracy and reliability of the reconstructed fiber orientations, numerical simulations are employed which use synthetic nerve fiber models as input. As the generation of fiber models can be challenging and very time-consuming, we have developed the open source FAConstructor tool which enables a fast and efficient generation of synthetic fiber models for 3D-PLI simulations.

Methods

The program was developed as an interactive tool, allowing the user to define fiber pathways with interpolation methods or parametric functions and providing visual feedba

SUBMITTER: Reuter JA 

PROVIDER: S-EPMC6851223 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature