Genetic Diversity and Spatial Segregation of Francisella tularensis Subspecies holarctica in Germany.

ABSTRACT: Francisella tularensis is an intracellular pleomorphic bacterium and the causative agent of tularemia, a zoonotic disease with a wide host range. Among the F. tularensis subspecies, especially F. tularensis subsp. holarctica is of clinical relevance for European countries. The study presented herein focuses namely on genetic diversity and spatial segregation of F. tularensis subsp. holarctica in Germany, as still limited information is available. The investigation is based on the analysis of 34 F. tularensis subsp. holarctica isolates and one draft genome from an outbreak strain. The isolates were cultured from sample material being that of primarily human patients (n = 25) and free-living animals (n = 9). For six of 25

SUBMITTER: Appelt S 

PROVIDER: S-EPMC6851236 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature