Spinal gastrin releasing peptide receptor expressing interneurons are controlled by local phasic and tonic inhibition.

ABSTRACT: Dorsal horn gastrin-releasing peptide receptor (GRPR) neurons have a central role in itch transmission. Itch signaling has been suggested to be controlled by an inhibitory network in the spinal dorsal horn, as increased scratching behavior can be induced by pharmacological disinhibition or ablation of inhibitory interneurons, but the direct influence of the inhibitory tone on the GRPR neurons in the itch pathway have not been explored. Here we have investigated spinal GRPR neurons through in vitro and bioinformatical analysis. Electrophysiological recordings revealed that GRPR neurons receive local spontaneous excitatory inputs transmitted by glutamate and inhibitory inputs by glycine and GABA, which were transmitted either by separate glycinergic and GABAergic synapses or by glycine and G

SUBMITTER: Freitag FB 

PROVIDER: S-EPMC6851355 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature