Validation of pediatric health-related quality of life instruments for primary ciliary dyskinesia (QOL-PCD).

ABSTRACT:

Rationale

Having developed the first disease-specific, health-related quality of life (HRQoL) instruments for children with primary ciliary dyskinesia (PCD), we aimed to assess the psychometric performance of quality of life (QOL)-PCD child, adolescent, and parent-proxy versions in terms of reliability and validity across cross-cultural settings and caring for patients with this rare disease.

Methods

Children (n = 71), adolescents (n = 85), and parents (n = 68) from multiple centers in the UK and North America completed age-appropriate QOL-PCD and generic QOL measures: pediatric QOL inventory, COPD assessment test (CAT), and Sino-Nasal Outcome Test 20. Total of 13 children, 13 parents, and 17 adolescents repeated QOL-PCD 10 to 14 days later to assess test-retest reliability.

SUBMITTER: Behan L 

PROVIDER: S-EPMC6851410 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature