Theoretical principles of deep brain stimulation induced synaptic suppression.

ABSTRACT:

Background

Deep brain stimulation (DBS) is a successful clinical therapy for a wide range of neurological disorders; however, the physiological mechanisms of DBS remain unresolved. While many different hypotheses currently exist, our analyses suggest that high frequency (∼100 Hz) stimulation-induced synaptic suppression represents the most basic concept that can be directly reconciled with experimental recordings of spiking activity in neurons that are being driven by DBS inputs.

Objective

The goal of this project was to develop a simple model system to characterize the excitatory post-synaptic currents (EPSCs) and action potential signaling generated in a neuron that is strongly connected to pre-synaptic glutamatergic inputs that are being directly activated by DBS.

Meth

SUBMITTER: Farokhniaee A 

PROVIDER: S-EPMC6851468 | biostudies-literature | 2019 Nov - Dec

REPOSITORIES: biostudies-literature