Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology.

ABSTRACT: Granulovacuolar degeneration bodies (GVBs) are membrane-bound vacuolar structures harboring a dense core that accumulate in the brains of patients with neurodegenerative disorders, including Alzheimer's disease and other tauopathies. Insight into the origin of GVBs and their connection to tau pathology has been limited by the lack of suitable experimental models for GVB formation. Here, we used confocal, automated, super-resolution and electron microscopy to demonstrate that the seeding of tau pathology triggers the formation of GVBs in different mouse models in vivo and in primary mouse neurons in vitro. Seeding-induced intracellular tau aggregation, but not seed exposure alone, causes GVB formation in cultured neurons, but not in astrocytes. The extent of tau pathology strongly correlate

SUBMITTER: Wiersma VI 

PROVIDER: S-EPMC6851499 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature