Survival of early posthematopoietic stem cell transplantation relapse of myeloid malignancies.

ABSTRACT:

Objective

Relapse of AML after allogeneic hematopoietic stem cell transplantation (HSCT) has a poor prognosis, and standard of care therapy is lacking. Early (<6 months) relapse is associated with dismal outcome, while the majority of relapses occur early after transplantation. A more precise indication which patients could benefit from reinduction therapy is warranted.

Methods

We retrospectively analyzed outcomes of 83 patients with postallogeneic HSCT relapse. Patients were divided based on intention to treat (curative vs supportive care).

Results

Of the 50 patients treated with curative intent, 44% reached complete remission (CR) upon reinduction chemotherapy, and of these patients, 50% survived. Two survivors reached CR after immunotherapy (donor lymphocyte infusi

SUBMITTER: de Jong G 

PROVIDER: S-EPMC6851577 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature