Neuromelanin or DaT-SPECT: which is the better marker for discriminating advanced Parkinson's disease?

ABSTRACT:

Background and purpose

Whether the neuromelanin-positive substantia nigra pars compacta area (NM-SNc) on neuromelanin magnetic resonance imaging (NM-MRI) and the specific binding ratio (SBR) on ¹²³ I-N-v-fluoropropyl-2b-carbomethoxy3b-(4-iodophenyl)nortropane single photon emission computed tomography (DaT-SPECT) can be correlated with motor fluctuations (MFs) in advanced Parkinson's disease (PD) was investigated.

Methods

Thirty-five PD patients (60 ± 13 years) and 23 healthy individuals as controls (59 ± 19 years) were enrolled. The relationships between NM-MRI and DaT-SPECT were prospectively examined in two subgroups divided according to the presence or absence of MFs. Multivariate analysis was performed using the Cox proportional hazard model to screen for ass

SUBMITTER: Okuzumi A 

PROVIDER: S-EPMC6851628 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature