Comparing Options for Deriving Chemical Ecotoxicity Hazard Values for the European Union Environmental Footprint, Part II.

ABSTRACT: Using the European Union's Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) ecotoxicity data, this paper compares 3 different approaches to calculate final substance toxicity hazard values using the USEtox approach (chronic EC50 + acute EC50/2), using only acute EC50 equivalent data (EC50_eq ), and using only chronic no observed effect concentration equivalent (NOEC_eq) data. About 4008, 4853, and 5560 substance hazard values could be calculated for the USEtox model, acute only, and chronic only approaches, respectively. The USEtox model provides hazard values similar to the ones based on acute EC50 data only. Although there is a large amount of variability in the ratios, the data support acute EC50_eq to chronic NOEC_eq r

SUBMITTER: Saouter E 

PROVIDER: S-EPMC6851631 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature