Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction.

ABSTRACT: Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to define the tumor origin and behavior beyond anatomical location. The gene expression profiles of 107 treatment-naïve, intestinal type, gastroesophageal adenocarcinomas were assessed by the Illumina-HTv4.0 beadchip. Differential gene expression (limma), unsupervised subgroup assignment (mclust) and pathway analysis (gage) were undertaken in R statistical computing and results were related to demographic and clinical parameters. Unsupervised assignment of the gene expression profiles revealed three distinct molecular subgroups, which were not as

SUBMITTER: Bornschein J 

PROVIDER: S-EPMC6851674 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature