Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early-stage oral squamous cell carcinoma.

ABSTRACT:

Aims

In the 8th edition of the American Joint Committee on Cancer TNM staging manual, tumour infiltration depth and extranodal extension are added to the pathological classification for oral squamous cell carcinoma. The currently available 8th TNM validation studies lack patients with conservative neck treatment, and changes in the classification especially affect patients with small tumours. The aim of this study was to determine the potential impact of the changes in the 8th edition pTNM classification on the prognosis and treatment strategy for oral squamous cell carcinoma in a well-defined series of pT1-T2 patients with long-term follow-up.

Methods and results

Two hundred and eleven first primary pT1-T2 oral squamous cell carcinoma patients, with surgical resection as pr

SUBMITTER: Boeve K 

PROVIDER: S-EPMC6851684 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature